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Applying for Natural Sciences at Cambridge: Subjects, Test and Interview

Applying for Natural Sciences at Cambridge: Subjects, Test and Interview

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11 November 2026
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Applying for Natural Sciences at Cambridge?

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Applying for Natural Sciences at Cambridge involves sitting the Engineering and Science Admissions Test (ESAT), submitting a UCAS application with a personal statement and, for those selected, attending interviews with academics at a College. Cambridge asks every Natural Sciences applicant to take ESAT Mathematics 1 plus two further modules, and requires Mathematics plus two other science or mathematics subjects at A level or IB Higher Level. The course is a three-year Tripos with an optional fourth year, whose first year combines three experimental subjects with one mathematics subject.

Applicants choose Biological or Physical Natural Sciences on the application, a choice that Cambridge says does not restrict first-year options and that helps Colleges assign interviewers. The ESAT is run by UAT-UK, a collaboration between Imperial College London and the University of Cambridge, and sat at Pearson test centres after registering in advance through the UAT-UK website. Colleges differ in some details of their process, so the admissions office of the chosen College is the place to confirm anything specific.

What is the Natural Sciences Tripos and how is it structured?

The Natural Sciences Tripos is Cambridge's broad science degree, taught over three years for a BA with an optional fourth year in some subjects leading to an MSci. Cambridge describes the first year, Part IA, as giving a wide scientific foundation with a strong mathematical base, and students choose three experimental subjects plus one mathematics subject.

Part IB moves towards areas of interest whilst keeping some breadth, with students taking three courses from options such as Cells to Organisms, Chemistry A or B, and Physics A or B. In Part II students either specialise in a single subject area, such as Genetics or Astrophysics, or follow a broader Biological or Physical Sciences route. Part III is the optional fourth year, offering advanced study in one area, often with a substantial research project, and progression depends on performance in the third year.

What are the entry requirements for Natural Sciences at Cambridge?

Cambridge requires Mathematics plus two other science or mathematics subjects, chosen from Biology, Chemistry, Physics or Further Mathematics, at A level or IB Higher Level. For the IB, Cambridge prefers Analysis and Approaches with Higher Level Mathematics for the Physical stream and recommends it for the Biological stream.

Individual first-year subjects have their own subject requirements, so the A levels a student takes affect how many Part IA options are open. Chemistry, for instance, lists A level Chemistry as essential, and Physics lists A level Physics or Further Mathematics, including the Mechanics section. Some Colleges also set their own subject requirements, which are worth checking on each College's pages before choosing one.

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Which ESAT modules does Cambridge ask for?

Cambridge asks Natural Sciences applicants to take Mathematics 1, which is compulsory, plus two further modules chosen from Biology, Chemistry, Physics and Mathematics 2. The test is computer-based and multiple-choice, made up of separate 40-minute modules sat back-to-back on the same day, so three modules take 120 minutes in total.

Cambridge states that applicants have free choice of the two additional modules when they sign up. Scores count correct answers only, with no penalty for wrong ones, so attempting every question is sensible. Registration in advance is required, applicants with access arrangements in their public exams can apply for the same arrangements, and the October sitting is the one Cambridge ESAT applicants use. A tutor can help a student practise the module combination that matches the A levels being studied.

How do the application and interview work?

Applicants submit a UCAS application with a personal statement, choose a College or make an open application, register for the ESAT in advance, and then complete the extra My Cambridge Application form after submitting UCAS. When applying, they specify Biological or Physical Natural Sciences, and Cambridge says this helps a College assign biological or physical sciences interviewers.

Cambridge describes interviews as academic conversations about the subject, assessing understanding, readiness for high-level study, critical and independent thinking, curiosity and enthusiasm. Most applicants have one or two interviews totalling between 35 minutes and an hour, though some have three or four, and interviews may be online or in person depending on the College. Everyone who receives an offer has been interviewed, but not everyone interviewed receives an offer.

What do the interviews involve across the subjects?

Natural Sciences interviews draw on subjects the applicant has already studied, with questions that depend on the chosen stream and current courses. Cambridge notes that interviewers may ask applicants to apply knowledge to new situations or problems, to discuss recent school topics or the personal statement, and, on science and mathematics courses, to share their workings on problem-solving questions.

Some applicants receive reading material beforehand, and some have a broader academic interview with academics from outside their subject. Cambridge advises reading the invitation carefully for timing, location and any pre-interview tasks, and points to its free Prepare for an interview guidance. The University does not endorse commercial tutoring services and states that they have no exclusive information about interviews, so practice is best aimed at explaining reasoning aloud.

How should first-year subject combinations be chosen?

Cambridge recommends choosing the entry route that best matches the student's strengths in their current studies. The first-year options include Biodiversity, Evolution and Ecology, Biomedical Sciences, Biomolecules and Cells, Chemistry, Earth Sciences, Materials Science and Physics, alongside Mathematics for Biological Sciences or Mathematics for Physical Sciences. A psychology-focused option is also mentioned, subject to timetable restrictions and student numbers.

Many of these options carry individual subject requirements, so the A levels or IB subjects a student is taking decide which combinations are open. Choosing Biological or Physical Natural Sciences on the application does not restrict Part IA choices, though some Colleges may ask for a further specialisation. Checking each option's requirements against the planned school subjects before applying avoids surprises later.

What super-curricular preparation helps?

Cambridge describes super-curricular activities as a way to engage with the chosen subject outside school or college, and points applicants to its Improve your application guidance. Its natsci.tripos.cam.ac.uk admissions page links to a Study Preparation section for further ideas.

In practice this means reading, lectures and problem-solving that extend what the student meets in Mathematics and the two or three sciences studied, linked to the first-year subjects of interest. Since interviews ask applicants to apply knowledge to unfamiliar problems and explain their workings, regular practice with problems beyond the syllabus, talking through the reasoning aloud, tends to be the most useful habit. A tutor can help a student practise this and prepare for the ESAT modules chosen.

How does it compare with single-subject degrees at Oxford or Cambridge?

Natural Sciences keeps the choice of specialism open until after the first year, whereas a single-subject degree at Oxford fixes the discipline at application. Oxford's admissions tests page lists the ESAT for Biomedical Sciences, Engineering Science and Physics, and no test for other courses, which means Oxford Chemistry and Biology applicants sit no admissions test.

Cambridge asks for the ESAT for Natural Sciences, with Mathematics 1 compulsory and two further modules chosen by the applicant. A student set on one discipline can specialise within Natural Sciences at Part II, with subjects such as Genetics or Astrophysics named by Cambridge. A student undecided between sciences gains breadth in the first year, and a student already certain may prefer to check each Oxford course page for its own entry requirements and test.

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Frequently asked questions

Which ESAT modules are required for Natural Sciences at Cambridge?
Cambridge requires Mathematics 1 for every Natural Sciences applicant, plus two further multiple-choice modules chosen from Biology, Chemistry, Physics and Mathematics 2. Cambridge states that applicants have free choice of the two additional modules when they sign up. Each module lasts 40 minutes, so the three modules take 120 minutes in total, and registration in advance is required.
What A levels are required for Natural Sciences at Cambridge?
Cambridge requires Mathematics plus two other science or mathematics subjects, chosen from Biology, Chemistry, Physics or Further Mathematics. Some first-year options and some Colleges ask for particular subjects, for example A level Chemistry for the Chemistry option. Checking the first-year options you hope to take against your subject choices is the safest approach.
Is it necessary to choose Biological or Physical Natural Sciences?
Yes, applicants are asked to specify Biological or Physical Natural Sciences when they apply. Cambridge says this selection does not restrict first-year choices and mainly helps a College assign biological or physical sciences interviewers. Some Colleges may ask for a further specialisation, so the College's own admissions pages are worth reading.
What happens in a Cambridge Natural Sciences interview?
Cambridge describes interviews as academic conversations about the subject. Applicants may apply knowledge to new problems, discuss recent school topics or their personal statement, and share their workings on problem-solving questions. Most have one or two interviews totalling between 35 minutes and an hour, online or in person depending on the College.
Does Oxford use the same test for Chemistry or Biology?
No. Oxford uses only the ESAT, TMUA, TARA, UCAT and LNAT, and its ESAT courses are Biomedical Sciences, Engineering Science, Physics, and Physics and Philosophy. Every other Oxford course, including Chemistry and Biology, has no admissions test. Applicants should check the individual Oxford course page for current requirements.

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